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Transplante heterotópico do cora？？o sem auxílio da circula？？o extracorpórea: estudo experimental em c？es
Carvalho, Roberto Gomes de;Krichenko, Antoninho;Giublin, Paulo;Varela, Alexandre;Amorim, Maria Jo？o;Bueno, Ronaldo Loures;Ribeiro, Edison José;Brofman, Paulo Roberto;Loures, Danton Rocha;
Revista Brasileira de Cirurgia Cardiovascular , 1986, DOI: 10.1590/S0102-76381986000200010
Abstract: the authors describe a new heterotopic heart transplantation technique. fourteen adult mongrel dogs were operated on via left lateral thoracotomy. only two vascular anastomosis were performed, without extra-corporeal circulation. the dogs tolerated well the procedure. cardiac catheterization demonstrated the method to be efficient. there is the possibility of applying this technique in humans.
Multimodal Stratified Approach for Prevention of Thromboembolism in Patients Undergoing Total Hip Arthroplasty  [PDF]
Elmano de Araújo Loures, Glauco Mendon？a Rocha, Daniel Naya Loures, Isabel Cristina Gon？alves Leite, Clarice Naya Loures
Open Journal of Orthopedics (OJO) , 2018, DOI: 10.4236/ojo.2018.812045
Abstract: Objective: To demonstrate the efficacy and safety of a multimodal stratified approach for prevention of thromboembolism in patients undergoing primary total hip arthroplasty. Method: A longitudinal retrospective clinical study of a cohort of 341 individuals undergoing total hip arthroplasty between March 2008 and July 2016. Of these, 242 patients met the criteria for inclusion in the study. Individuals with a history of deep vein thrombosis or pulmonary thromboembolism, thrombophilia, hypercoagulation conditions, and chronic users of anticoagulants before surgery received enoxaparin at a dose of 40 mg/day for 21 days. For the other group, acetylsalicylic acid was prescribed at a dose of 200 mg/day for 30 days. All patients had surgical risk assessed by the American Anesthesiology Association classified as I or II, and underwent regional anesthesia, effective hydration, the same protocol of early postoperative rehabilitation, and the use of compression stockings. Drug cost analysis was performed based on the Brasíndice. To date, there are no publications in PubMed and Scielo on this subject regarding the Brazilian population. Results: The need for blood transfusion in the enoxaparin group was higher and the overall complication and hemorrhagic rates were also significantly higher (p < 0.010) in this group. Aspirin prescription costs 39 times less than enoxaparin. Conclusion: In patients without predisposing factors to thromboembolism and undergoing primary total hip arthroplasty, the multimodal approach with acetylsalicylic acid seems to be effective, with low cost and a low rate of complications.
Tumores cardíacos: 10 anos de experiência
MIANA Ant？nio Augusto,PASSOS Pedro Horácio Cocenza,WHITAKER Joseph Fredric,LOURES Jo？o Batista Lopes
Revista Brasileira de Cirurgia Cardiovascular , 1997,
Abstract: Objetivo: Avaliar a experiência cirúrgica do grupo no tratamento dos tumores cardíacos durante o período de janeiro de 1985 a dezembro de 1994. Casuística e Métodos: De um total de 2268 cirurgias cardíacas com circula o extracorpórea realizadas neste período de 10 anos, 6 foram para extirpa o de tumores intracavitários, perfazendo 0,26% dos casos. Destes, 3 eram mixomas de átrio esquerdo, 1 fibroelastoma papilar de valva mitral, 1 rabdomioma de ventrículo esquerdo e 1 fibroma de ventrículo esquerdo. A forma clínica de apresenta o foi embolia sistêmica (3 casos) ou insuficiência cardíaca (3 casos). O diagnóstico foi ecocardiográfico (5 casos) e angiográfico (6 casos). Resultados: Todos os pacientes tiveram evolu o imediata favorável, exceto 1 deles, com mixoma de átrio equerdo, que evoluiu com mediastinite e septicemia, vindo a falecer e constituindo o único óbito hospitalar. O seguimento pós-operatório tardio, obtido em 4 pacientes (15 a 111 meses - média 49 ± 36,8 meses), n o detectou qualquer recidiva, encontrando-se todos em classe funcional I (NYHA). Conclus es: Os autores concluem que os tumores cardíacos s o bastante raros, de fácil diagnóstico desde que considerados, na grande maioria benignos e que cursam favoravelmente com a extirpa o cirúrgica.
Feed restriction and a diet's caloric value: The influence on the aerobic and anaerobic capacity of rats
Leandro de Moura, Carlos Kalva-Filho, Jo？o Loures, Maria de Sousa Silva, Lucas Zorzetto, Marcelo Junior, Michel de Araújo, Rodrigo Dalia, Maria de Mello
Journal of the International Society of Sports Nutrition , 2012, DOI: 10.1186/1550-2783-9-10
Abstract: We used 40 adult Wistar rats. The animals were divided into four groups: ad libitum commercial Purina？ diet (3028.0 Kcal/kg) (ALP), restricted commercial Purina？ diet (RAP), ad libitum semi-purified AIN-93 diet (3802.7 Kcal/kg) (ALD) and restricted semi-purified AIN-93 diet (RAD). The animals performed LM at the end of the experiment, 48 h before euthanasia. Comparisons between groups were performed by analysis of variance (p < 0,05).At the end of the experiment, the weights of the rats in the groups with the restricted diets were significantly lower than those in the groups with ad libitum diet intakes. In addition, the ALD group had higher amounts of adipose tissue. With respect to energetic substrates, the groups subjected to diet restriction had significantly higher levels of liver and muscle glycogen. There were no differences between the groups with respect to AT; however, the ALD group had lower lactatemia at the AT intensity and higher Tlim than the other groups.We conclude that dietary restriction induces changes in energetic substrates and that ad libitum intake of a semi-purified AIN-93 diet results in an increase in adipose tissue, likely reducing the density of the animals in water and favouring their performance during the swimming exercises.Several authors have studied the effects of caloric restriction on body composition and metabolic variables in both humans [1-3] and animals [4]. Reducing daily feed intake to 20 to 40% below ad libitum levels, or providing feed intermittently rather than continuously, has been found to significantly reduce the risk of chronic degenerative diseases such as cancer, type-II diabetes and kidney diseases, and to prolong the life span of laboratory rats and mice by 40% without causing malnutrition [4-7].However, excessive dietary restriction can lead to malnutrition and physiological changes that lead to decreases in sympathetic nervous system activity, changes in thyroid metabolism, reductions in insulin concentrations
Síndrome do roubo coronário-subclávio: relato de caso e revis？o da literatura
Miiller, Jean Carlo;Candemil, Patrick Cardoso;Loures, Jo？o Marcelo Goncalves da Rocha;Zucco, Fabrício Martins;Belz, Walmor Erwin;Loures, Nilceu Gomes da Rocha;Ortiz, Marco Rodrigo;Garcia, Rogério Sanchez;
Jornal Vascular Brasileiro , 2012, DOI: 10.1590/S1677-54492012000200017
Abstract: the phenomenon of coronary-subclavian steal is defined as the reversed blood flow in a coronary artery, through internal mammary artery graft towards medial-distal subclavian artery, which happens due to severe stenosis or total occlusion of the proximal portion of the latter. it is a rare but significant cause of cardiac ischemia after coronary artery bypass surgery and it can cause a syndrome of the same name and with typical manifestations. we have reported the case of a patient with this disease, who underwent percutaneous angioplasty with stent implantation, and we also reviewed the literature on the subject.
Aneurisma adquirido de aorta ascendente em crian？a
Loures, Danton R. da Rocha;Ferreira, Maria Jo？o Amorim;Almeida, Rui Sequeira de;Bueno, Ronaldo Loures;Krichenko, Antoninho;Brofman, Paulo R;Ribeiro, Edison José;Linhares, Lauro;Costa, Mário Lobato da;Seegmuller, Edimara;
Revista Brasileira de Cirurgia Cardiovascular , 1989, DOI: 10.1590/S0102-76381989000100011
Abstract: acquired aneurysm of the ascending aorta is a rare condition in the pediatric age group. the authors present two cases of 6 and 12 year old boys with saccular aneurysm of the ascending aorta and aortic stenosis, which underwent successful surgical correction.
Produ？？o e qualidade do tomate produzido em substrato, no campo e em ambiente protegido
Fontes, Paulo Cezar R.;Loures, Juvenal L.;Galv？o, Jo？o Carlos C.;Cardoso, Ant？nio Américo;Mantovani, Everardo C.;
Horticultura Brasileira , 2004, DOI: 10.1590/S0102-05362004000300023
Abstract: the tomato (hybrid carmen) fruit yield and quality in the fito system were evaluated, using plastic bags containing organic compost + sand + nutrients, in the field and under unheated greenhouse conditions. seven treatments were evaluated: 1) fito, under unheated greenhouse, using perforated plastic bags, with 9 dm3 substratum per plant, containing 25% of organic compost and 75% of sand, all the macro and micronutrientes being added through trickle irrigation; 2) fito a, similar to the previous treatment, except that only sand was used as substratum; 3) fito 1, similar to fito, except that the n and k were applied through trickle irrigation and the other nutrients were directly mixed in the substratum; 4) check plot in unheated greenhouse in which plants were directly transplanted in the soil; 5) fito c, similar to fito, except that the plants were cultivated under field condition; 6) check plot in unheated greenhouse in which plants were transplanted to the soil n and k being applied through trickle irrigation; 7) check plot with plants directly transplanted in the soil under field conditions. the experiment was conducted in randomized blocks design with four repetitions. there was no significant effect of treatments on n, zn and mn contents in leaf; in big and small sized fruits; in total fruit yield and fruit quality (ph, acidity, total soluble solids and vitamin c). significant differences were found among treatments for leaf dry weight, medium, commercial and non-commercial production of fruits per day after transplantation (pcd). significant differences were observed for p, k, ca, mg, s, fe and cu contents in leaves. the highest commercial, weighted and pcd yields, 104.79 t ha-1, 94,71 t ha-1 and 0.851 t ha-1 day-1, respectively, were obtained with the fito system. however these values did not differ from those observed in the check plot using soil in the unheated greenhouse. fito system can substitute the cultivation in the soil, either in the field or in unh
Florística, estrutura e características do solo de um fragmento de floresta paludosa no sudeste do Brasil
Loures, Laércio;Carvalho, Douglas Ant？nio de;Machado, Evandro Luiz Mendon？a;Marques, Jo？o José Granate de Sá e Melo;
Acta Botanica Brasilica , 2007, DOI: 10.1590/S0102-33062007000400013
Abstract: a survey of the tree community was conducted for an upland semideciduous riparian forest, located on the upper rio pardo, santa rita de caldas, minas gerais (1156 to 1203 m altitude), in order to evaluate structural variation and environmental variables associated with the substrate. density, basal area, tree size distribution and floristic composition were evaluated. in 25 10x40 m plots, all trees with dbh > 5 cm were sampled, topographical aspects were determined and soil samples were collected for chemical and textural analyses. a total of 2982 individuals from 50 families, 78 genera and 110 species were recorded. a sequence of three soil subgroups (organosoil, melanic gleisoil and haplic gleisoil) was registered in a downstream direction. floristic composition and structure the tree community was different from other swamp and alluvial forests of southern and southeastern brazil, at lower altitudes. canonical correspondence analysis detected a tree-species distribution gradient correlated mainly with clay content and elevation variation.
Valor prognóstico dos critérios de obesidade em pacientes submetidos a interven？？o coronária percutanea
Tarastchuk, José Carlos Estival;Bueno, Ronaldo da Rocha Loures;Andrade, Paulo Maurício Piá de;Nercolini, Deborah Christina;Guérios, ênio Eduardo;Ferraz, Jo？o Gustavo Gongora;
Revista Brasileira de Cardiologia Invasiva , 2008, DOI: 10.1590/S2179-83972008000100011
Abstract: background: no evidence supports obesity cutoff points recommended by literature for the brazilian population. some female/male known cutoff points are: waist circumference (wc) 80/90cm, waist-to-hip ratio (whr) 0.80/0.90, conicity index (ci) 1.18/1.25, body mass index (bmi) 30. these cutoff points need to be validated for the brazilian population as prognostic after percutaneous coronary intervention (pci). objective: to verify cutoff points of obesity anthropometric indexes in this population and to compare them to international diabetes federation values for latin america in determining mace after pci. methods: 308 patients (mean age 61.92 ± 11.06 years old, 60.7% men) undergoing successful pci. six months after, patients were contacted for clinical follow-up. mace included death, acute myocardial infarction, cardiac surgery, reintervention or evidence of myocardial ischemia in a non-invasive test. patients were divided into 2 groups: group 1 (with mace, n = 91), group 2 (without mace, n = 217). in order to obtain cutoff points, roc curves were plotted based on anthropometric indexes and mace. results: the cutoff points obtained for women were: wc 102cm, whr 0.93, ci 1.18 and bmi 24.53. compared with idf values, wc and whr obtained had more specificity (76.83% x 31.71% and 43.9% x 7.32%), bmi had more sensibility (66.67% x 20.51%). for men, the cutoff points were: wc 102 cm, whr 0.94, ci 1.24 and bmi 24.98. wc and whr had more specificity (69.63% x 45.19% and 7.41% x 2.94%). bmi and ci had more sensibility (65.38% x 28.85% and 55.77% x 53.85%). conclusion: cutoff points of anthropometric indexes of this population that better correlate with mace are different than the literature. our results suggest that, for prognostic information, we need specific anthropometric cutoff points for each population or disease.
Associa？？o rara entre lúpus eritematoso sistêmico, obesidade mórbida e Síndrome de Takotsubo
Meyer Neto, Jo？o Gaspar Corrêa;Benchimol, Claudio Buarque;Penna, Guilherme Loures;Carvalho, Luiz Ant？nio Ferreira;Pessoa, Maria Carolina;
Arquivos Brasileiros de Cardiologia , 2006, DOI: 10.1590/S0066-782X2006001700028
Abstract: the authors report a 68-year-old white female with long-term systemic lupus erythematosus as well as morbid obesity, characterized by very elevated body mass index, who presented a classical picture of acute coronary failure ascribed to takotsubo syndrome.
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